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Tensions in the Middle East escalated dramatically Saturday after Donald Trump confirmed that the United States launched “major combat operations in Iran” as part of a joint U.S.-Israel military campaign.

The operation—named Operation Epic Fury—targeted Iranian military and government sites, according to U.S. and Israeli officials. Iran has vowed retaliation, with missile and drone strikes reported across the region.

Trump Confirms “Major Combat Operations” in Iran

In a video statement posted to social media, Trump said the objective was to eliminate “imminent threats” posed by the Iranian regime.

“Our objective is to defend the American people,” Trump stated, adding that American casualties are possible as the operation unfolds.

U.S. officials indicated the military campaign could last several days.

Casualties Reported After Strike on Iranian Elementary School

Iranian officials reported that a strike hit a girls’ elementary school in Minab, resulting in significant casualties.

Reported School Strike Casualties

Iran claims the school was struck during the joint U.S.-Israeli military operation. There has been no immediate independent confirmation.

Iranian Foreign Minister Abbas Araghchi condemned the attack and vowed retaliation.

Iran Launches Missiles at Israel, US Bases Targeted

Following the initial strikes, Iran’s Islamic Revolutionary Guard Corps (IRGC) claimed it launched missiles and drones targeting:

• U.S. Navy Fifth Fleet headquarters in Bahrain
• U.S. bases in Qatar and the UAE
• Israeli military and security facilities

The Israel Defense Forces reported additional waves of missiles launched toward Israeli territory, with air defense systems activated.

Netanyahu: Operation to Remove “Existential Threat”

Israeli Prime Minister Benjamin Netanyahu described the campaign as an effort to eliminate what he called an “existential threat” posed by Iran.

Netanyahu stated that Israel and the United States coordinated closely in the months leading up to the operation.

Iran’s Leadership Allegedly Targeted

Sources briefed on the operation told media outlets that both Iran’s Supreme Leader Ali Khamenei and President Masoud Pezeshkian were among the intended targets of the strikes.

Iran has not confirmed any injuries to senior leadership.

US Political Reaction: War Powers Debate Intensifies

Sen. Tim Kaine called for the Senate to reconvene and vote on a war powers resolution to check presidential authority, labeling the military action “a colossal mistake.”

The debate raises constitutional questions over congressional authorization for extended military engagement.

Regional Impact and Civilian Casualties

Missile alerts were reported across central Israel. The United Arab Emirates confirmed one civilian death due to falling debris from intercepted missiles.

The U.S. embassy in Qatar issued emergency alerts warning Americans of imminent missile threats.

Key Developments Timeline

Could This Lead to Regime Change?

Trump publicly called for regime change, urging Iranians to “take over your government.” While the U.S. has not formally declared regime change policy, rhetoric suggests broader strategic goals beyond immediate military deterrence.

Whether Iran’s leadership structure faces internal instability remains uncertain, but the conflict significantly raises geopolitical stakes.

FAQ: US-Iran-Israel Conflict 2026

1. Why did the US launch strikes on Iran?

The U.S. cited imminent threats from Iran and concerns over nuclear weapons development.

2. What is Operation Epic Fury?

It is the official name of the U.S. military campaign targeting Iranian military and government sites.

3. Were Iranian leaders targeted?

Sources indicate Supreme Leader Ali Khamenei and President Pezeshkian were targeted, though Iran has not confirmed details.

4. How has Iran responded?

Iran launched missiles and drones targeting Israel and U.S. military bases in the region.

5. Are civilian casualties confirmed?

Iran reports dozens of children killed in a school strike; independent verification remains limited.

6. Could the conflict expand regionally?

Yes. Attacks on U.S. bases and missile exchanges increase the risk of broader Middle East escalation.

What Happens Next?

With missile exchanges ongoing and U.S. officials warning the campaign may last days, global markets and diplomatic channels remain on edge. The possibility of regional expansion—and broader global consequences—remains a key concern as developments continue to unfold.